This is the service for searching contact molecules with similar proteins to a given query sequence
|UniProt ID||CDK3_HUMAN [link]|
|UniProt AC||Q00526 [link]|
|INSDC protein_id||AAV40830.1 [link]|
|RefSeq protein_id||NP_001249.1 [link]|
Notes for input the query sequence
|Summary Bars||Full Bars||Site Table|
|Icons on the page top|
|Descriptions||Showiing aligned regions of homologous structure as a colored-bar under the horizontal bar of the query sequence.|
Showing only representative homologous structure.
|Showiing aligned regions of homologous structure as a colored-bar under the horizontal bar of the query sequence.|
Showing all the homologous structure.
|Summary as "one site for one row" format.|
|Examples of the query PPARD_HUMAN|
On the top of the windows, some common links and tables are shown among the three views.
The homologous complexes are classified into seven classes: "HETERO", "NUCLEOTIDE", "COMPOUND", "METAL", "OTHERPOLY", "HOMO", PRECIPITANT"".
Aligned regions are shown in gray bars, and residue contacting the other molecule are shown in small red boxes.
The column "contact_mol" in the middle of the table shows contacting molecules with query's homologues. The column "homologue" shows a homologous protein with the query. In the column "identity[%]", two sequence identities are shown, such as "92.3/72.3". The first number is the sequence identity of the contact site, and the second number is the identiy of all the aligned residues. The identity of the contact sites is a good measure for the qualit of the model, especially for the small chemical compound. In the column "Ncon", two number of contacting residues are shown, such as "13/13". The first number is the number of contact in the aligned regions, the second number is the number of contact sites in all the template sites. If the first number is much smaller than the second, the model can be built by a quite small part of the template complex 3D structures.
[n]:site number of query sequence. [a]:amino acid of query sequence. [s]:predicted secondary structure from homolgous structure."H":alpha-helix, "E":beta-strand, "T":turn. [e]:predicted solvent accessible state. "e":exposed, "b":buried [acc]:predicted relative accesssibility[%]. [pdb]:PDB code of homologous structure. [contact_mols]:binding other molecules [observed aa]:Observed amino acids among homologous sequences. [feature table]:UniProt Feature Table [variant]:UniProt Human Variant.If you click the icon in the left column, the summary page of the specific site appears.A following page is the summary of the 223-rd site of PPARD_HUMAN.
If you click the icon in "Templates for 3D complexes"、a following 3D model page is shown for the 3D complex model where the focused site contacts to other molecule.