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PID

QueryLength

Homolgous Sequence in PDB

UniProt Query

TITLE

57782

468

P08887(IL6RA_HUMAN)

RecName: Full=Interleukin-6 receptor subunit alpha ; Short=IL-6 receptor subunit alpha; Short=IL-6R subunit alpha; Short=IL-6R-alpha; Short=IL-6RA;AltName: Full=IL-6R 1;AltName: Full=Membrane glycoprotein 80; Short=gp80;AltName: CD_antigen=CD126;Contains: RecName: Full=Soluble interleukin-6 receptor subunit alpha ; Short=sIL6R ;Flags: Precursor;

QUERYSEQ

MLAVGCALLAALLAAPGAALAPRRCPAQEVARGVLTSLPGDSVTLTCPGVEPEDNATVHWVLRKPAAGSHPSRWAGMGRRLLLRSVQLHDSGNYSCYRAGRPAGTVHLLVDVPPEEPQLSCFRKSPLSNVVCEWGPRSTPSLTTKAVLLV
RKFQNSPAEDFQEPCQYSQESQKFSCQLAVPEGDSSFYIVSMCVASSVGSKFSKTQTFQGCGILQPDPPANITVTAVARNPRWLSVTWQDPHSWNSSFYRLRFELRYRAERSKTFTTWMVKDLQHHCVIHDAWSGLRHVVQLRAQEEFGQ
GEWSEWSPEAMGTPWTESRSPPAENEVSTPMQALTTNKDDDNILFRDSANATSLPVQDSSSVPLPTFLVAGGSLAFGTLLCIAIVLRFKKTWKLRALKEGKTSMHPPYSLGQLVPERPRPTPVLVPLISPPVSPSSLGSDNTSSHNRPDA
RDPRSPYDISNTDYFFPR

[BLAST file for PDB] (plain) (bar) (multiple alignment) [BLAST for UniProt: (plain) (bar) (multiple alignment) (PSSM file) ]

UniProt Feature Tables [P08887(IL6RA_HUMAN)]

468
	region	name	description
	1-19	SIGNAL
	20-468	CHAIN	/note="Interleukin-6 receptor subunit alpha" /id="PRO_0000010895"
	20-355	CHAIN	/note="Soluble interleukin-6 receptor subunit alpha" /id="PRO_0000450730"
	20-365	TOPO_DOM	/note="Extracellular"
	366-386	TRANSMEM	/note="Helical"
	387-468	TOPO_DOM	/note="Cytoplasmic"
	26-112	DOMAIN	/note="Ig-like C2-type"
	113-217	DOMAIN	/note="Fibronectin type-III 1"
	218-316	DOMAIN	/note="Fibronectin type-III 2"
	1-468	DISORDER	predicted by DISOPRED (1-18,313-331,333-334,341-352,354-354,358-358,406-413,420-468)

MONOMER

468

pdb_id a¹ identity[%]² description

1n26 A 100.0 IL6A_HUMAN IL-6 Receptor alpha chain

1.a¹:asym_id for the homologue. 2.identity[%]²:sequence identity between the query and the homologue.

HETERO

468 pdb_id contact mol homologue

a³ description a⁴ identity[%]⁵ Ncon⁶ description

1p9m[2] A IL6RB_HUMAN Interleukin-6 receptor beta chain[298 aa] C 100.0
/100.0 8
/8 IL6RA_HUMAN Interleukin-6 receptor alpha chain

1p9m[2] A IL6RB_HUMAN Interleukin-6 receptor beta chain[298 aa] C 100.0
/100.0 12
/12 IL6RA_HUMAN Interleukin-6 receptor alpha chain

5fuc[1] E VHH6[110 aa] C 100.0
/99.0 10
/10 D6R9R8_HUMAN IL6RA_HUMAN INTERLEUKIN-6 RECEPTOR SUBUNIT ALPHA, INTERLEUKIN-..

5fuc[1] F VHH6[124 aa] D 100.0
/99.0 10
/10 D6R9R8_HUMAN IL6RA_HUMAN INTERLEUKIN-6 RECEPTOR SUBUNIT ALPHA, INTERLEUKIN-..

5fuc[1] A IL6_HUMAN INTERLEUKIN-6[152 aa] D 100.0
/99.0 12
/12 D6R9R8_HUMAN IL6RA_HUMAN INTERLEUKIN-6 RECEPTOR SUBUNIT ALPHA, INTERLEUKIN-..

1f45[1] B I12A_HUMAN INTERLEUKIN-12 ALPHA CHAIN[133 aa] A 25.0
/30.4 20
/21 I12B_HUMAN INTERLEUKIN-12 BETA CHAIN

1pvh[2] B LIF_HUMAN Leukemia inhibitory factor[169 aa] A 23.1
/29.9 13
/13 IL6RB_HUMAN Interleukin-6 receptor beta chain

4grw[2] E Nanobody 124C4[125 aa] D 21.4
/28.5 14
/16 IL12B_HUMAN Interleukin-12 subunit beta

4grw[2] F Nanobody 37D5[125 aa] D 25.0
/28.5 4
/4 IL12B_HUMAN Interleukin-12 subunit beta

4grw[3] I Nanobody 22E11[123 aa] D 9.1
/28.5 11
/18 IL12B_HUMAN Interleukin-12 subunit beta

5njd[8] F IL23A_HUMAN Interleukin-23 subunit alpha[146 aa] E 20.0
/28.8 15
/16 IL12B_HUMAN Interleukin-12 subunit beta

6uib[1] A IL23A_HUMAN Interleukin-23 subunit alpha[132 aa] B 12.5
/28.6 16
/17 IL12B_HUMAN Interleukin-12 subunit beta

3d85[2] C IL23A_HUMAN Interleukin-23 subunit p19[133 aa] D 12.5
/28.3 16
/17 IL12B_HUMAN Interleukin-12 subunit p40

3hmx[1] D USTEKINUMAB FAB HEAVY CHAIN[217 aa] A 25.0
/29.0 12
/13 IL12B_HUMAN Interleukin-12 subunit beta

4i18[1] C antibody light chain[215 aa] E 60.0
/24.9 5
/5 PRLR_HUMAN Prolactin receptor

3hmx[1] C USTEKINUMAB FAB LIGHT CHAIN[214 aa] A 14.3
/29.0 7
/9 IL12B_HUMAN Interleukin-12 subunit beta

3hmx[1] B IL12A_HUMAN Interleukin-12 subunit alpha[176 aa] A 17.6
/29.0 17
/18 IL12B_HUMAN Interleukin-12 subunit beta

1p9m[2] C IL6RA_HUMAN Interleukin-6 receptor alpha chain[201 aa] A 10.0
/28.9 10
/11 IL6RB_HUMAN Interleukin-6 receptor beta chain

5fuc[1] B IL6_HUMAN INTERLEUKIN-6[160 aa] C 100.0
/99.0 18
/18 D6R9R8_HUMAN IL6RA_HUMAN INTERLEUKIN-6 RECEPTOR SUBUNIT ALPHA, INTERLEUKIN-..

1p9m[2] B IL6_HUMAN Interleukin-6[163 aa] C 100.0
/100.0 15
/15 IL6RA_HUMAN Interleukin-6 receptor alpha chain

1p9m[2] B IL6_HUMAN Interleukin-6[163 aa] A 33.3
/28.9 12
/12 IL6RB_HUMAN Interleukin-6 receptor beta chain

3qwr[1] C ADNECTIN[91 aa] A 28.6
/28.9 21
/22 IL12B_HUMAN Interleukin-12 subunit beta

6uib[1] C Peptide 23-652[15 aa] B 25.0
/28.6 12
/12 IL12B_HUMAN Interleukin-12 subunit beta

5njd[1] J IL23A_HUMAN Interleukin-23 subunit alpha[141 aa] I 18.8
/28.6 16
/16 IL12B_HUMAN Interleukin-12 subunit beta

3duh[1] C IL23A_HUMAN Interleukin-23 subunit alpha[137 aa] A 13.3
/28.6 15
/16 IL12B_HUMAN Interleukin-12 subunit beta

3duh[1] D IL23A_HUMAN Interleukin-23 subunit alpha[137 aa] B 12.5
/28.5 16
/17 IL12B_HUMAN Interleukin-12 subunit beta

5njd[6] V Briakinumab FAb Heavy chain[205 aa] A 0.0
/27.9 2
/10 IL12B_HUMAN Interleukin-12 subunit beta

5njd[6] U Briakinumab FAb Light chain[215 aa] A 0.0
/27.9 3
/8 IL12B_HUMAN Interleukin-12 subunit beta

3d87[4] C IL23A_HUMAN Interleukin-23 subunit p19[159 aa] D 18.8
/28.9 16
/17 IL12B_HUMAN Interleukin-12 subunit p40

3d87[1] C IL23A_HUMAN Interleukin-23 subunit p19[159 aa] B 0.0
/28.8 2
/2 IL12B_HUMAN Interleukin-12 subunit p40

1i1r[2] B Q98823_HHV8 VIRAL IL-6[167 aa] A 36.4
/28.2 11
/11 IL6RB_HUMAN INTERLEUKIN-6 RECEPTOR BETA CHAIN

5mzv[1] B IL23A_HUMAN Interleukin-23 subunit alpha[137 aa] A 18.8
/28.0 16
/17 IL12B_HUMAN Interleukin-12 subunit beta

5mzv[1] C IL23R_HUMAN Interleukin-23 receptor[293 aa] A 0.0
/28.0 2
/6 IL12B_HUMAN Interleukin-12 subunit beta

3ew3[1] A PRL_HUMAN Prolactin[185 aa] B 0.0
/25.4 20
/21 PRLR_RAT Prolactin receptor

1f6f[1] A CSH_SHEEP PLACENTAL LACTOGEN[183 aa] B 4.5
/25.3 22
/23 PRLR_RAT PROLACTIN RECEPTOR

3d48[1] A PRL_HUMAN Prolactin[165 aa] B 0.0
/25.1 21
/22 PRLR_HUMAN Prolactin receptor

4i18[1] D antibody heavy chain[220 aa] E 20.0
/24.9 20
/21 PRLR_HUMAN Prolactin receptor

3n0p[9] A PRL_HUMAN Prolactin[186 aa] B 0.0
/24.7 21
/22 PRLR_HUMAN Prolactin receptor

3.a³:asym_id for the contact molecule. 4.a⁴:asym_id for the template homologue. 5.identity[%]⁵:sequence identity between the query and the template homologue only for the contact residues. Number after the slash / is sequence identity for all the aligned region. 6.Ncon⁶:number of aligned contact residues for the query. Number after the slash / is number of contact residues in the template homologue.

COMPOUND

468 pdb_id contact mol homologue

a³ description a⁴ identity[%]⁵ Ncon⁶ description

1n26[2] H CYS
CYSTEINE[7 atoms] A 100.0
/100.0 5
/5 IL6A_HUMAN IL-6 Receptor alpha chain

1n26[4] E NAG
2-acetamido-2-deoxy-beta-D-glucopyranose[14 atoms].. A 100.0
/100.0 3
/3 IL6A_HUMAN IL-6 Receptor alpha chain

6o4p[1] E NAG
2-acetamido-2-deoxy-beta-D-glucopyranose[14 atoms].. A 50.0
/35.0 4
/4 I11RA_HUMAN Interleukin-11 receptor subunit alpha

1n26[1] E NAG
2-acetamido-2-deoxy-beta-D-glucopyranose[14 atoms].. A 100.0
/100.0 3
/3 IL6A_HUMAN IL-6 Receptor alpha chain

1n26[2] D NAG
2-acetamido-2-deoxy-beta-D-glucopyranose[14 atoms].. A 100.0
/100.0 5
/5 IL6A_HUMAN IL-6 Receptor alpha chain

6uib[2] E NAG
N-ACETYL-D-GLUCOSAMINE[14 atoms] B 0.0
/28.6 1
/3 IL12B_HUMAN Interleukin-12 subunit beta

3duh[2] E NAG
2-acetamido-2-deoxy-beta-D-glucopyranose[14 atoms].. A 0.0
/28.6 2
/7 IL12B_HUMAN Interleukin-12 subunit beta

5fuc[2] I NAG
2-acetamido-2-deoxy-beta-D-glucopyranose[14 atoms].. D 100.0
/99.0 2
/2 D6R9R8_HUMAN IL6RA_HUMAN INTERLEUKIN-6 RECEPTOR SUBUNIT ALPHA, INTERLEUKIN-..

1f42[1] D MNB
5-MERCAPTO-2-NITRO-BENZOIC ACID[13 atoms] A 50.0
/28.9 6
/6 I12B_HUMAN INTERLEUKIN-12 BETA CHAIN

1f42[1] C MNB
5-MERCAPTO-2-NITRO-BENZOIC ACID[13 atoms] A 66.7
/28.9 3
/3 I12B_HUMAN INTERLEUKIN-12 BETA CHAIN

3d87[1] G MAN
alpha-D-mannopyranose[11 atoms] D 0.0
/28.9 4
/4 IL12B_HUMAN Interleukin-12 subunit p40

3.a³:asym_id for the contact molecule. 4.a⁴:asym_id for the template homologue. 5.identity[%]⁵:sequence identity between the query and the template homologue only for the contact residues. Number after the slash / is sequence identity for all the aligned region. 6.Ncon⁶:number of aligned contact residues for the query. Number after the slash / is number of contact residues in the template homologue.

METAL

468 pdb_id contact mol homologue

a³ description a⁴ identity[%]⁵ Ncon⁶ description

1pvh[1] E IOD
IODIDE ION[1 atoms] A 100.0
/29.9 1
/1 IL6RB_HUMAN Interleukin-6 receptor beta chain

3d87[2] I K
POTASSIUM ION[1 atoms] D 25.0
/28.9 4
/4 IL12B_HUMAN Interleukin-12 subunit p40

3ncb[7] G NA
SODIUM ION[1 atoms] B 40.0
/24.7 5
/5 PRLR_HUMAN Prolactin receptor

3mzg[7] C NA
SODIUM ION[1 atoms] B 0.0
/24.7 2
/2 PRLR_HUMAN Prolactin receptor

3n0p[7] C NA
SODIUM ION[1 atoms] B 0.0
/24.7 5
/5 PRLR_HUMAN Prolactin receptor

5mj3[1] I NA
SODIUM ION[1 atoms] A 0.0
/28.3 3
/3 IL12B_HUMAN Interleukin-12 subunit beta

5mj3[1] H NA
SODIUM ION[1 atoms] A 33.3
/28.3 3
/3 IL12B_HUMAN Interleukin-12 subunit beta

3nce[1] C NA
SODIUM ION[1 atoms] B 0.0
/24.7 2
/3 PRLR_HUMAN Prolactin receptor

5mzv[1] K NA
SODIUM ION[1 atoms] A 100.0
/28.0 1
/1 IL12B_HUMAN Interleukin-12 subunit beta

3ncf[7] E CL
CHLORIDE ION[1 atoms] B 50.0
/24.7 2
/2 PRLR_HUMAN Prolactin receptor

5mzv[1] J CL
CHLORIDE ION[1 atoms] A 0.0
/28.0 2
/3 IL12B_HUMAN Interleukin-12 subunit beta

3.a³:asym_id for the contact molecule. 4.a⁴:asym_id for the template homologue. 5.identity[%]⁵:sequence identity between the query and the template homologue only for the contact residues. Number after the slash / is sequence identity for all the aligned region. 6.Ncon⁶:number of aligned contact residues for the query. Number after the slash / is number of contact residues in the template homologue.

OTHERPOLY

468 pdb_id contact mol homologue

a³ description a⁴ identity[%]⁵ Ncon⁶ description

1n26[2] B 2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-4)-al.. A 100.0
/100.0 9
/9 IL6A_HUMAN IL-6 Receptor alpha chain

1n26[2] C 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-a.. A 100.0
/100.0 5
/5 IL6A_HUMAN IL-6 Receptor alpha chain

3l5h[1] B 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-a.. A 50.0
/28.8 2
/2 IL6RB_HUMAN Interleukin-6 receptor subunit beta

6o4p[1] D 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-a.. B 0.0
/35.4 4
/4 I11RA_HUMAN Interleukin-11 receptor subunit alpha

5njd[8] Y alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose.. A 25.0
/27.9 4
/8 IL12B_HUMAN Interleukin-12 subunit beta

3hmx[3] E alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose.. A 0.0
/29.0 3
/7 IL12B_HUMAN Interleukin-12 subunit beta

1f45[2] C alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-be.. A 0.0
/30.4 3
/7 I12B_HUMAN INTERLEUKIN-12 BETA CHAIN

3l5h[1] C beta-D-mannopyranose-(1-4)-beta-D-mannopyranose-(1.. A 0.0
/28.8 1
/1 IL6RB_HUMAN Interleukin-6 receptor subunit beta

5mzv[1] E alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-.. A 25.0
/28.0 4
/10 IL12B_HUMAN Interleukin-12 subunit beta

6o4p[1] C alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(.. A 0.0
/35.0 5
/5 I11RA_HUMAN Interleukin-11 receptor subunit alpha

3qwr[1] D alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(.. A 0.0
/28.9 3
/7 IL12B_HUMAN Interleukin-12 subunit beta

5mxa[1] C alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(.. B 0.0
/28.0 2
/8 IL12B_HUMAN Interleukin-12 subunit beta

3.a³:asym_id for the contact molecule. 4.a⁴:asym_id for the template homologue. 5.identity[%]⁵:sequence identity between the query and the template homologue only for the contact residues. Number after the slash / is sequence identity for all the aligned region. 6.Ncon⁶:number of aligned contact residues for the query. Number after the slash / is number of contact residues in the template homologue.

HOMO

468 pdb_id contact mol homologue

a³ description a⁴ identity[%]⁵ Ncon⁶ description

1n26[1] A IL6A_HUMAN IL-6 Receptor alpha chain[299 aa] A 100.0
/100.0 15
/15 IL6A_HUMAN IL-6 Receptor alpha chain

1n26[1] A IL6A_HUMAN IL-6 Receptor alpha chain[299 aa] A 100.0
/100.0 11
/11 IL6A_HUMAN IL-6 Receptor alpha chain

1bqu[1] B IL6RB_HUMAN PROTEIN (GP130)[215 aa] A 33.3
/30.2 9
/9 IL6RB_HUMAN PROTEIN (GP130)

1bqu[1] A IL6RB_HUMAN PROTEIN (GP130)[208 aa] B 20.0
/29.9 10
/11 IL6RB_HUMAN PROTEIN (GP130)

3npz[2] B PRLR_RAT Prolactin receptor[202 aa] C 15.4
/26.1 13
/15 PRLR_RAT Prolactin receptor

3ew3[1] C PRLR_RAT Prolactin receptor[181 aa] B 10.0
/25.4 10
/11 PRLR_RAT Prolactin receptor

1f6f[1] C PRLR_RAT PROLACTIN RECEPTOR[169 aa] B 10.0
/25.3 10
/11 PRLR_RAT PROLACTIN RECEPTOR

3.a³:asym_id for the contact molecule. 4.a⁴:asym_id for the template homologue. 5.identity[%]⁵:sequence identity between the query and the template homologue only for the contact residues. Number after the slash / is sequence identity for all the aligned region. 6.Ncon⁶:number of aligned contact residues for the query. Number after the slash / is number of contact residues in the template homologue.

PRECIPITANT

468 pdb_id contact mol homologue

a³ description a⁴ identity[%]⁵ Ncon⁶ description

6o4p[2] K SO4
SULFATE ION[5 atoms] A 0.0
/35.0 2
/2 I11RA_HUMAN Interleukin-11 receptor subunit alpha

1bqu[1] J SO4
SULFATE ION[5 atoms] B 0.0
/29.9 3
/3 IL6RB_HUMAN PROTEIN (GP130)

6o4p[7] H SO4
SULFATE ION[5 atoms] A 0.0
/35.0 4
/4 I11RA_HUMAN Interleukin-11 receptor subunit alpha

1bqu[3] D SO4
SULFATE ION[5 atoms] A 0.0
/30.2 1
/1 IL6RB_HUMAN PROTEIN (GP130)

6o4p[1] M SO4
SULFATE ION[5 atoms] B 0.0
/35.4 3
/3 I11RA_HUMAN Interleukin-11 receptor subunit alpha

1n26[2] G SO4
SULFATE ION[5 atoms] A 100.0
/100.0 3
/3 IL6A_HUMAN IL-6 Receptor alpha chain

6o4p[1] P SO4
SULFATE ION[5 atoms] B 0.0
/35.4 1
/1 I11RA_HUMAN Interleukin-11 receptor subunit alpha

6o4p[1] L SO4
SULFATE ION[5 atoms] B 0.0
/35.4 2
/2 I11RA_HUMAN Interleukin-11 receptor subunit alpha

3l5h[1] I SO4
SULFATE ION[5 atoms] A 0.0
/28.8 1
/1 IL6RB_HUMAN Interleukin-6 receptor subunit beta

1n26[2] F SO4
SULFATE ION[5 atoms] A 100.0
/100.0 3
/3 IL6A_HUMAN IL-6 Receptor alpha chain

1bqu[1] I SO4
SULFATE ION[5 atoms] B 0.0
/29.9 2
/2 IL6RB_HUMAN PROTEIN (GP130)

3l5h[1] J SO4
SULFATE ION[5 atoms] A 0.0
/28.8 1
/1 IL6RB_HUMAN Interleukin-6 receptor subunit beta

6o4p[1] I SO4
SULFATE ION[5 atoms] A 0.0
/35.0 1
/3 I11RA_HUMAN Interleukin-11 receptor subunit alpha

1bqu[1] F GOL
GLYCEROL[6 atoms] A 50.0
/30.2 6
/6 IL6RB_HUMAN PROTEIN (GP130)

1bqu[1] L GOL
GLYCEROL[6 atoms] B 50.0
/29.9 6
/6 IL6RB_HUMAN PROTEIN (GP130)

4i18[1] K GOL
GLYCEROL[6 atoms] E 83.3
/24.9 6
/6 PRLR_HUMAN Prolactin receptor

1bqu[2] K GOL
GLYCEROL[6 atoms] B 33.3
/29.9 6
/6 IL6RB_HUMAN PROTEIN (GP130)

1bqu[1] M GOL
GLYCEROL[6 atoms] B 25.0
/29.9 4
/4 IL6RB_HUMAN PROTEIN (GP130)

3d87[2] E PO4
PHOSPHATE ION[5 atoms] B 50.0
/28.8 2
/2 IL12B_HUMAN Interleukin-12 subunit p40

5mj3[1] G PGE
TRIETHYLENE GLYCOL[10 atoms] A 75.0
/28.3 4
/4 IL12B_HUMAN Interleukin-12 subunit beta

3d48[1] E CO3
CARBONATE ION[4 atoms] B 75.0
/25.1 4
/4 PRLR_HUMAN Prolactin receptor

3ncc[1] G CO3
CARBONATE ION[4 atoms] B 0.0
/24.7 2
/2 PRLR_HUMAN Prolactin receptor

3d48[1] D CO3
CARBONATE ION[4 atoms] B 50.0
/25.1 2
/2 PRLR_HUMAN Prolactin receptor

3d48[1] F CO3
CARBONATE ION[4 atoms] B 12.5
/25.1 8
/8 PRLR_HUMAN Prolactin receptor

4i18[1] L ACT
ACETATE ION[4 atoms] E 0.0
/24.9 2
/2 PRLR_HUMAN Prolactin receptor

3.a³:asym_id for the contact molecule. 4.a⁴:asym_id for the template homologue. 5.identity[%]⁵:sequence identity between the query and the template homologue only for the contact residues. Number after the slash / is sequence identity for all the aligned region. 6.Ncon⁶:number of aligned contact residues for the query. Number after the slash / is number of contact residues in the template homologue.

MONOMER
468
	pdb_id	a¹	identity[%]²	description
	1n26	A	100.0	IL6A_HUMAN IL-6 Receptor alpha chain
	1.a¹:asym_id for the homologue. 2.identity[%]²:sequence identity between the query and the homologue.

HETERO
468	pdb_id	contact mol		homologue
	pdb_id	a³	description	a⁴	identity[%]⁵	Ncon⁶	description
	1p9m[2]	A	IL6RB_HUMAN Interleukin-6 receptor beta chain[298 aa]	C	100.0 /100.0	8 /8	IL6RA_HUMAN Interleukin-6 receptor alpha chain
	1p9m[2]	A	IL6RB_HUMAN Interleukin-6 receptor beta chain[298 aa]	C	100.0 /100.0	12 /12	IL6RA_HUMAN Interleukin-6 receptor alpha chain
	5fuc[1]	E	VHH6[110 aa]	C	100.0 /99.0	10 /10	D6R9R8_HUMAN IL6RA_HUMAN INTERLEUKIN-6 RECEPTOR SUBUNIT ALPHA, INTERLEUKIN-..
	5fuc[1]	F	VHH6[124 aa]	D	100.0 /99.0	10 /10	D6R9R8_HUMAN IL6RA_HUMAN INTERLEUKIN-6 RECEPTOR SUBUNIT ALPHA, INTERLEUKIN-..
	5fuc[1]	A	IL6_HUMAN INTERLEUKIN-6[152 aa]	D	100.0 /99.0	12 /12	D6R9R8_HUMAN IL6RA_HUMAN INTERLEUKIN-6 RECEPTOR SUBUNIT ALPHA, INTERLEUKIN-..
	1f45[1]	B	I12A_HUMAN INTERLEUKIN-12 ALPHA CHAIN[133 aa]	A	25.0 /30.4	20 /21	I12B_HUMAN INTERLEUKIN-12 BETA CHAIN
	1pvh[2]	B	LIF_HUMAN Leukemia inhibitory factor[169 aa]	A	23.1 /29.9	13 /13	IL6RB_HUMAN Interleukin-6 receptor beta chain
	4grw[2]	E	Nanobody 124C4[125 aa]	D	21.4 /28.5	14 /16	IL12B_HUMAN Interleukin-12 subunit beta
	4grw[2]	F	Nanobody 37D5[125 aa]	D	25.0 /28.5	4 /4	IL12B_HUMAN Interleukin-12 subunit beta
	4grw[3]	I	Nanobody 22E11[123 aa]	D	9.1 /28.5	11 /18	IL12B_HUMAN Interleukin-12 subunit beta
	5njd[8]	F	IL23A_HUMAN Interleukin-23 subunit alpha[146 aa]	E	20.0 /28.8	15 /16	IL12B_HUMAN Interleukin-12 subunit beta
	6uib[1]	A	IL23A_HUMAN Interleukin-23 subunit alpha[132 aa]	B	12.5 /28.6	16 /17	IL12B_HUMAN Interleukin-12 subunit beta
	3d85[2]	C	IL23A_HUMAN Interleukin-23 subunit p19[133 aa]	D	12.5 /28.3	16 /17	IL12B_HUMAN Interleukin-12 subunit p40
	3hmx[1]	D	USTEKINUMAB FAB HEAVY CHAIN[217 aa]	A	25.0 /29.0	12 /13	IL12B_HUMAN Interleukin-12 subunit beta
	4i18[1]	C	antibody light chain[215 aa]	E	60.0 /24.9	5 /5	PRLR_HUMAN Prolactin receptor
	3hmx[1]	C	USTEKINUMAB FAB LIGHT CHAIN[214 aa]	A	14.3 /29.0	7 /9	IL12B_HUMAN Interleukin-12 subunit beta
	3hmx[1]	B	IL12A_HUMAN Interleukin-12 subunit alpha[176 aa]	A	17.6 /29.0	17 /18	IL12B_HUMAN Interleukin-12 subunit beta
	1p9m[2]	C	IL6RA_HUMAN Interleukin-6 receptor alpha chain[201 aa]	A	10.0 /28.9	10 /11	IL6RB_HUMAN Interleukin-6 receptor beta chain
	5fuc[1]	B	IL6_HUMAN INTERLEUKIN-6[160 aa]	C	100.0 /99.0	18 /18	D6R9R8_HUMAN IL6RA_HUMAN INTERLEUKIN-6 RECEPTOR SUBUNIT ALPHA, INTERLEUKIN-..
	1p9m[2]	B	IL6_HUMAN Interleukin-6[163 aa]	C	100.0 /100.0	15 /15	IL6RA_HUMAN Interleukin-6 receptor alpha chain
	1p9m[2]	B	IL6_HUMAN Interleukin-6[163 aa]	A	33.3 /28.9	12 /12	IL6RB_HUMAN Interleukin-6 receptor beta chain
	3qwr[1]	C	ADNECTIN[91 aa]	A	28.6 /28.9	21 /22	IL12B_HUMAN Interleukin-12 subunit beta
	6uib[1]	C	Peptide 23-652[15 aa]	B	25.0 /28.6	12 /12	IL12B_HUMAN Interleukin-12 subunit beta
	5njd[1]	J	IL23A_HUMAN Interleukin-23 subunit alpha[141 aa]	I	18.8 /28.6	16 /16	IL12B_HUMAN Interleukin-12 subunit beta
	3duh[1]	C	IL23A_HUMAN Interleukin-23 subunit alpha[137 aa]	A	13.3 /28.6	15 /16	IL12B_HUMAN Interleukin-12 subunit beta
	3duh[1]	D	IL23A_HUMAN Interleukin-23 subunit alpha[137 aa]	B	12.5 /28.5	16 /17	IL12B_HUMAN Interleukin-12 subunit beta
	5njd[6]	V	Briakinumab FAb Heavy chain[205 aa]	A	0.0 /27.9	2 /10	IL12B_HUMAN Interleukin-12 subunit beta
	5njd[6]	U	Briakinumab FAb Light chain[215 aa]	A	0.0 /27.9	3 /8	IL12B_HUMAN Interleukin-12 subunit beta
	3d87[4]	C	IL23A_HUMAN Interleukin-23 subunit p19[159 aa]	D	18.8 /28.9	16 /17	IL12B_HUMAN Interleukin-12 subunit p40
	3d87[1]	C	IL23A_HUMAN Interleukin-23 subunit p19[159 aa]	B	0.0 /28.8	2 /2	IL12B_HUMAN Interleukin-12 subunit p40
	1i1r[2]	B	Q98823_HHV8 VIRAL IL-6[167 aa]	A	36.4 /28.2	11 /11	IL6RB_HUMAN INTERLEUKIN-6 RECEPTOR BETA CHAIN
	5mzv[1]	B	IL23A_HUMAN Interleukin-23 subunit alpha[137 aa]	A	18.8 /28.0	16 /17	IL12B_HUMAN Interleukin-12 subunit beta
	5mzv[1]	C	IL23R_HUMAN Interleukin-23 receptor[293 aa]	A	0.0 /28.0	2 /6	IL12B_HUMAN Interleukin-12 subunit beta
	3ew3[1]	A	PRL_HUMAN Prolactin[185 aa]	B	0.0 /25.4	20 /21	PRLR_RAT Prolactin receptor
	1f6f[1]	A	CSH_SHEEP PLACENTAL LACTOGEN[183 aa]	B	4.5 /25.3	22 /23	PRLR_RAT PROLACTIN RECEPTOR
	3d48[1]	A	PRL_HUMAN Prolactin[165 aa]	B	0.0 /25.1	21 /22	PRLR_HUMAN Prolactin receptor
	4i18[1]	D	antibody heavy chain[220 aa]	E	20.0 /24.9	20 /21	PRLR_HUMAN Prolactin receptor
	3n0p[9]	A	PRL_HUMAN Prolactin[186 aa]	B	0.0 /24.7	21 /22	PRLR_HUMAN Prolactin receptor
	3.a³:asym_id for the contact molecule. 4.a⁴:asym_id for the template homologue. 5.identity[%]⁵:sequence identity between the query and the template homologue only for the contact residues. Number after the slash / is sequence identity for all the aligned region. 6.Ncon⁶:number of aligned contact residues for the query. Number after the slash / is number of contact residues in the template homologue.
COMPOUND
468	pdb_id	contact mol		homologue
	pdb_id	a³	description	a⁴	identity[%]⁵	Ncon⁶	description
	1n26[2]	H	CYS CYSTEINE[7 atoms]	A	100.0 /100.0	5 /5	IL6A_HUMAN IL-6 Receptor alpha chain
	1n26[4]	E	NAG 2-acetamido-2-deoxy-beta-D-glucopyranose[14 atoms]..	A	100.0 /100.0	3 /3	IL6A_HUMAN IL-6 Receptor alpha chain
	6o4p[1]	E	NAG 2-acetamido-2-deoxy-beta-D-glucopyranose[14 atoms]..	A	50.0 /35.0	4 /4	I11RA_HUMAN Interleukin-11 receptor subunit alpha
	1n26[1]	E	NAG 2-acetamido-2-deoxy-beta-D-glucopyranose[14 atoms]..	A	100.0 /100.0	3 /3	IL6A_HUMAN IL-6 Receptor alpha chain
	1n26[2]	D	NAG 2-acetamido-2-deoxy-beta-D-glucopyranose[14 atoms]..	A	100.0 /100.0	5 /5	IL6A_HUMAN IL-6 Receptor alpha chain
	6uib[2]	E	NAG N-ACETYL-D-GLUCOSAMINE[14 atoms]	B	0.0 /28.6	1 /3	IL12B_HUMAN Interleukin-12 subunit beta
	3duh[2]	E	NAG 2-acetamido-2-deoxy-beta-D-glucopyranose[14 atoms]..	A	0.0 /28.6	2 /7	IL12B_HUMAN Interleukin-12 subunit beta
	5fuc[2]	I	NAG 2-acetamido-2-deoxy-beta-D-glucopyranose[14 atoms]..	D	100.0 /99.0	2 /2	D6R9R8_HUMAN IL6RA_HUMAN INTERLEUKIN-6 RECEPTOR SUBUNIT ALPHA, INTERLEUKIN-..
	1f42[1]	D	MNB 5-MERCAPTO-2-NITRO-BENZOIC ACID[13 atoms]	A	50.0 /28.9	6 /6	I12B_HUMAN INTERLEUKIN-12 BETA CHAIN
	1f42[1]	C	MNB 5-MERCAPTO-2-NITRO-BENZOIC ACID[13 atoms]	A	66.7 /28.9	3 /3	I12B_HUMAN INTERLEUKIN-12 BETA CHAIN
	3d87[1]	G	MAN alpha-D-mannopyranose[11 atoms]	D	0.0 /28.9	4 /4	IL12B_HUMAN Interleukin-12 subunit p40
	3.a³:asym_id for the contact molecule. 4.a⁴:asym_id for the template homologue. 5.identity[%]⁵:sequence identity between the query and the template homologue only for the contact residues. Number after the slash / is sequence identity for all the aligned region. 6.Ncon⁶:number of aligned contact residues for the query. Number after the slash / is number of contact residues in the template homologue.
METAL
468	pdb_id	contact mol		homologue
	pdb_id	a³	description	a⁴	identity[%]⁵	Ncon⁶	description
	1pvh[1]	E	IOD IODIDE ION[1 atoms]	A	100.0 /29.9	1 /1	IL6RB_HUMAN Interleukin-6 receptor beta chain
	3d87[2]	I	K POTASSIUM ION[1 atoms]	D	25.0 /28.9	4 /4	IL12B_HUMAN Interleukin-12 subunit p40
	3ncb[7]	G	NA SODIUM ION[1 atoms]	B	40.0 /24.7	5 /5	PRLR_HUMAN Prolactin receptor
	3mzg[7]	C	NA SODIUM ION[1 atoms]	B	0.0 /24.7	2 /2	PRLR_HUMAN Prolactin receptor
	3n0p[7]	C	NA SODIUM ION[1 atoms]	B	0.0 /24.7	5 /5	PRLR_HUMAN Prolactin receptor
	5mj3[1]	I	NA SODIUM ION[1 atoms]	A	0.0 /28.3	3 /3	IL12B_HUMAN Interleukin-12 subunit beta
	5mj3[1]	H	NA SODIUM ION[1 atoms]	A	33.3 /28.3	3 /3	IL12B_HUMAN Interleukin-12 subunit beta
	3nce[1]	C	NA SODIUM ION[1 atoms]	B	0.0 /24.7	2 /3	PRLR_HUMAN Prolactin receptor
	5mzv[1]	K	NA SODIUM ION[1 atoms]	A	100.0 /28.0	1 /1	IL12B_HUMAN Interleukin-12 subunit beta
	3ncf[7]	E	CL CHLORIDE ION[1 atoms]	B	50.0 /24.7	2 /2	PRLR_HUMAN Prolactin receptor
	5mzv[1]	J	CL CHLORIDE ION[1 atoms]	A	0.0 /28.0	2 /3	IL12B_HUMAN Interleukin-12 subunit beta
	3.a³:asym_id for the contact molecule. 4.a⁴:asym_id for the template homologue. 5.identity[%]⁵:sequence identity between the query and the template homologue only for the contact residues. Number after the slash / is sequence identity for all the aligned region. 6.Ncon⁶:number of aligned contact residues for the query. Number after the slash / is number of contact residues in the template homologue.
OTHERPOLY
468	pdb_id	contact mol		homologue
	pdb_id	a³	description	a⁴	identity[%]⁵	Ncon⁶	description
	1n26[2]	B	2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-4)-al..	A	100.0 /100.0	9 /9	IL6A_HUMAN IL-6 Receptor alpha chain
	1n26[2]	C	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-a..	A	100.0 /100.0	5 /5	IL6A_HUMAN IL-6 Receptor alpha chain
	3l5h[1]	B	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-a..	A	50.0 /28.8	2 /2	IL6RB_HUMAN Interleukin-6 receptor subunit beta
	6o4p[1]	D	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-a..	B	0.0 /35.4	4 /4	I11RA_HUMAN Interleukin-11 receptor subunit alpha
	5njd[8]	Y	alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose..	A	25.0 /27.9	4 /8	IL12B_HUMAN Interleukin-12 subunit beta
	3hmx[3]	E	alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose..	A	0.0 /29.0	3 /7	IL12B_HUMAN Interleukin-12 subunit beta
	1f45[2]	C	alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-be..	A	0.0 /30.4	3 /7	I12B_HUMAN INTERLEUKIN-12 BETA CHAIN
	3l5h[1]	C	beta-D-mannopyranose-(1-4)-beta-D-mannopyranose-(1..	A	0.0 /28.8	1 /1	IL6RB_HUMAN Interleukin-6 receptor subunit beta
	5mzv[1]	E	alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-..	A	25.0 /28.0	4 /10	IL12B_HUMAN Interleukin-12 subunit beta
	6o4p[1]	C	alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(..	A	0.0 /35.0	5 /5	I11RA_HUMAN Interleukin-11 receptor subunit alpha
	3qwr[1]	D	alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(..	A	0.0 /28.9	3 /7	IL12B_HUMAN Interleukin-12 subunit beta
	5mxa[1]	C	alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(..	B	0.0 /28.0	2 /8	IL12B_HUMAN Interleukin-12 subunit beta
	3.a³:asym_id for the contact molecule. 4.a⁴:asym_id for the template homologue. 5.identity[%]⁵:sequence identity between the query and the template homologue only for the contact residues. Number after the slash / is sequence identity for all the aligned region. 6.Ncon⁶:number of aligned contact residues for the query. Number after the slash / is number of contact residues in the template homologue.
HOMO
468	pdb_id	contact mol		homologue
	pdb_id	a³	description	a⁴	identity[%]⁵	Ncon⁶	description
	1n26[1]	A	IL6A_HUMAN IL-6 Receptor alpha chain[299 aa]	A	100.0 /100.0	15 /15	IL6A_HUMAN IL-6 Receptor alpha chain
	1n26[1]	A	IL6A_HUMAN IL-6 Receptor alpha chain[299 aa]	A	100.0 /100.0	11 /11	IL6A_HUMAN IL-6 Receptor alpha chain
	1bqu[1]	B	IL6RB_HUMAN PROTEIN (GP130)[215 aa]	A	33.3 /30.2	9 /9	IL6RB_HUMAN PROTEIN (GP130)
	1bqu[1]	A	IL6RB_HUMAN PROTEIN (GP130)[208 aa]	B	20.0 /29.9	10 /11	IL6RB_HUMAN PROTEIN (GP130)
	3npz[2]	B	PRLR_RAT Prolactin receptor[202 aa]	C	15.4 /26.1	13 /15	PRLR_RAT Prolactin receptor
	3ew3[1]	C	PRLR_RAT Prolactin receptor[181 aa]	B	10.0 /25.4	10 /11	PRLR_RAT Prolactin receptor
	1f6f[1]	C	PRLR_RAT PROLACTIN RECEPTOR[169 aa]	B	10.0 /25.3	10 /11	PRLR_RAT PROLACTIN RECEPTOR
	3.a³:asym_id for the contact molecule. 4.a⁴:asym_id for the template homologue. 5.identity[%]⁵:sequence identity between the query and the template homologue only for the contact residues. Number after the slash / is sequence identity for all the aligned region. 6.Ncon⁶:number of aligned contact residues for the query. Number after the slash / is number of contact residues in the template homologue.
PRECIPITANT
468	pdb_id	contact mol		homologue
	pdb_id	a³	description	a⁴	identity[%]⁵	Ncon⁶	description
	6o4p[2]	K	SO4 SULFATE ION[5 atoms]	A	0.0 /35.0	2 /2	I11RA_HUMAN Interleukin-11 receptor subunit alpha
	1bqu[1]	J	SO4 SULFATE ION[5 atoms]	B	0.0 /29.9	3 /3	IL6RB_HUMAN PROTEIN (GP130)
	6o4p[7]	H	SO4 SULFATE ION[5 atoms]	A	0.0 /35.0	4 /4	I11RA_HUMAN Interleukin-11 receptor subunit alpha
	1bqu[3]	D	SO4 SULFATE ION[5 atoms]	A	0.0 /30.2	1 /1	IL6RB_HUMAN PROTEIN (GP130)
	6o4p[1]	M	SO4 SULFATE ION[5 atoms]	B	0.0 /35.4	3 /3	I11RA_HUMAN Interleukin-11 receptor subunit alpha
	1n26[2]	G	SO4 SULFATE ION[5 atoms]	A	100.0 /100.0	3 /3	IL6A_HUMAN IL-6 Receptor alpha chain
	6o4p[1]	P	SO4 SULFATE ION[5 atoms]	B	0.0 /35.4	1 /1	I11RA_HUMAN Interleukin-11 receptor subunit alpha
	6o4p[1]	L	SO4 SULFATE ION[5 atoms]	B	0.0 /35.4	2 /2	I11RA_HUMAN Interleukin-11 receptor subunit alpha
	3l5h[1]	I	SO4 SULFATE ION[5 atoms]	A	0.0 /28.8	1 /1	IL6RB_HUMAN Interleukin-6 receptor subunit beta
	1n26[2]	F	SO4 SULFATE ION[5 atoms]	A	100.0 /100.0	3 /3	IL6A_HUMAN IL-6 Receptor alpha chain
	1bqu[1]	I	SO4 SULFATE ION[5 atoms]	B	0.0 /29.9	2 /2	IL6RB_HUMAN PROTEIN (GP130)
	3l5h[1]	J	SO4 SULFATE ION[5 atoms]	A	0.0 /28.8	1 /1	IL6RB_HUMAN Interleukin-6 receptor subunit beta
	6o4p[1]	I	SO4 SULFATE ION[5 atoms]	A	0.0 /35.0	1 /3	I11RA_HUMAN Interleukin-11 receptor subunit alpha
	1bqu[1]	F	GOL GLYCEROL[6 atoms]	A	50.0 /30.2	6 /6	IL6RB_HUMAN PROTEIN (GP130)
	1bqu[1]	L	GOL GLYCEROL[6 atoms]	B	50.0 /29.9	6 /6	IL6RB_HUMAN PROTEIN (GP130)
	4i18[1]	K	GOL GLYCEROL[6 atoms]	E	83.3 /24.9	6 /6	PRLR_HUMAN Prolactin receptor
	1bqu[2]	K	GOL GLYCEROL[6 atoms]	B	33.3 /29.9	6 /6	IL6RB_HUMAN PROTEIN (GP130)
	1bqu[1]	M	GOL GLYCEROL[6 atoms]	B	25.0 /29.9	4 /4	IL6RB_HUMAN PROTEIN (GP130)
	3d87[2]	E	PO4 PHOSPHATE ION[5 atoms]	B	50.0 /28.8	2 /2	IL12B_HUMAN Interleukin-12 subunit p40
	5mj3[1]	G	PGE TRIETHYLENE GLYCOL[10 atoms]	A	75.0 /28.3	4 /4	IL12B_HUMAN Interleukin-12 subunit beta
	3d48[1]	E	CO3 CARBONATE ION[4 atoms]	B	75.0 /25.1	4 /4	PRLR_HUMAN Prolactin receptor
	3ncc[1]	G	CO3 CARBONATE ION[4 atoms]	B	0.0 /24.7	2 /2	PRLR_HUMAN Prolactin receptor
	3d48[1]	D	CO3 CARBONATE ION[4 atoms]	B	50.0 /25.1	2 /2	PRLR_HUMAN Prolactin receptor
	3d48[1]	F	CO3 CARBONATE ION[4 atoms]	B	12.5 /25.1	8 /8	PRLR_HUMAN Prolactin receptor
	4i18[1]	L	ACT ACETATE ION[4 atoms]	E	0.0 /24.9	2 /2	PRLR_HUMAN Prolactin receptor
	3.a³:asym_id for the contact molecule. 4.a⁴:asym_id for the template homologue. 5.identity[%]⁵:sequence identity between the query and the template homologue only for the contact residues. Number after the slash / is sequence identity for all the aligned region. 6.Ncon⁶:number of aligned contact residues for the query. Number after the slash / is number of contact residues in the template homologue.

Summary Bars[0 %]

UniProt Feature Tables [P08887(IL6RA_HUMAN)]