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PID QueryLength Homolgous Sequence in PDB UniProt Query TITLE
35431 529 13 P52292(IMA1_HUMAN) RecName: Full=Importin subunit alpha-1 {ECO:0000305};AltName: Full=Karyopherin subunit alpha-2;AltName: Full=RAG cohort protein 1;AltName: Full=SRP1-alpha;
QUERYSEQ
MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASG
TSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVK
LLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQA
AEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF
[BLAST file for PDB] (plain) (bar) (multiple alignment) [BLAST for UniProt: (plain) (bar) (multiple alignment) (PSSM file) ]

UniProt Feature Tables [P52292(IMA1_HUMAN)]

529
region name description
2-529 CHAIN /note="Importin subunit alpha-1" /id="PRO_0000120722"
2-60 DOMAIN /note="IBB"
71-111 REPEAT /note="ARM 1; truncated"
112-151 REPEAT /note="ARM 2"
152-193 REPEAT /note="ARM 3"
200-244 REPEAT /note="ARM 4"
246-282 REPEAT /note="ARM 5"
283-322 REPEAT /note="ARM 6"
325-364 REPEAT /note="ARM 7"
367-409 REPEAT /note="ARM 8"
410-456 REPEAT /note="ARM 9"
457-496 REPEAT /note="ARM 10; atypical"
142-238 REGION /note="NLS binding site (major)"
315-403 REGION /note="NLS binding site (minor)"
28-31 COMPBIAS /note="Poly-Arg"
499-502 COMPBIAS /note="Poly-Glu"
1-529 DISORDER predicted by DISOPRED (1-42,49-51,53-70,500-529)

MONOMER
529
pdb_id a1 identity[%]2 description
5h43 A 100.0 IMA1_HUMAN Importin subunit alpha-1
1qgk B 100.0 IMA2_HUMAN PROTEIN (IMPORTIN ALPHA-2 SUBUNIT)
1.a1:asym_id for the homologue. 2.identity[%]2:sequence identity between the query and the homologue.
HETERO
529 pdb_id contact mol homologue
a3 description a4 identity[%]5 Ncon6 description
3fey[2] A NCBP1_HUMAN Nuclear cap-binding protein subunit 1[761 aa] C 100.0
/100.0
40
/40
IMA2_HUMAN Importin subunit alpha-2
4wv6[1] B TAF8_HUMAN Transcription initiation factor TFIID subunit 8[9 .. A 100.0
/100.0
20
/20
IMA1_HUMAN Importin subunit alpha-1
4wv6[1] C TAF8_HUMAN Transcription initiation factor TFIID subunit 8[3 .. A 100.0
/100.0
8
/8
IMA1_HUMAN Importin subunit alpha-1
5h43[1] C KAT8_HUMAN Histone acetyltransferase KAT8[15 aa] A 100.0
/100.0
30
/30
IMA1_HUMAN Importin subunit alpha-1
5h43[1] B KAT8_HUMAN Histone acetyltransferase KAT8[10 aa] A 100.0
/100.0
21
/21
IMA1_HUMAN Importin subunit alpha-1
1qgr[2] A IMB1_HUMAN PROTEIN (IMPORTIN BETA SUBUNIT)[872 aa] B 100.0
/100.0
14
/14
IMA2_HUMAN PROTEIN (IMPORTIN ALPHA-2 SUBUNIT)
3tj3[2] D NUP50_HUMAN Nuclear pore complex protein Nup50[50 aa] C 44.7
/31.2
47
/47
IMA1_HUMAN Importin subunit alpha-1
2jdq[2] D PB2_IAVI7 POLYMERASE BASIC PROTEIN 2[65 aa] A 56.9
/31.4
51
/51
IMA1_HUMAN IMPORTIN ALPHA-1 SUBUNIT
4b18[1] B TERT_HUMAN TELOMERASE REVERSE TRANSCRIPTASE[16 aa] A 57.1
/31.1
35
/35
IMA1_HUMAN IMPORTIN SUBUNIT ALPHA-1
3.a3:asym_id for the contact molecule. 4.a4:asym_id for the template homologue. 5.identity[%]5:sequence identity between the query and the template homologue only for the contact residues. Number after the slash / is sequence identity for all the aligned region. 6.Ncon6:number of aligned contact residues for the query. Number after the slash / is number of contact residues in the template homologue.
HOMO
529 pdb_id contact mol homologue
a3 description a4 identity[%]5 Ncon6 description
2jdq[1] A IMA1_HUMAN IMPORTIN ALPHA-1 SUBUNIT[424 aa] B 29.4
/31.2
17
/17
IMA1_HUMAN IMPORTIN ALPHA-1 SUBUNIT
2jdq[1] B IMA1_HUMAN IMPORTIN ALPHA-1 SUBUNIT[426 aa] A 20.0
/31.4
15
/15
IMA1_HUMAN IMPORTIN ALPHA-1 SUBUNIT
3.a3:asym_id for the contact molecule. 4.a4:asym_id for the template homologue. 5.identity[%]5:sequence identity between the query and the template homologue only for the contact residues. Number after the slash / is sequence identity for all the aligned region. 6.Ncon6:number of aligned contact residues for the query. Number after the slash / is number of contact residues in the template homologue.
PRECIPITANT
529 pdb_id contact mol homologue
a3 description a4 identity[%]5 Ncon6 description
3wpt[2] C PEG
DI(HYDROXYETHYL)ETHER[7 atoms]
A 100.0
/100.0
2
/2
IMA1_HUMAN Importin subunit alpha-1
3wpt[2] N PEG
DI(HYDROXYETHYL)ETHER[7 atoms]
B 100.0
/100.0
4
/4
IMA1_HUMAN Importin subunit alpha-1
3wpt[2] O PEG
DI(HYDROXYETHYL)ETHER[7 atoms]
B 100.0
/100.0
2
/2
IMA1_HUMAN Importin subunit alpha-1
3wpt[1] P PEG
DI(HYDROXYETHYL)ETHER[7 atoms]
B 100.0
/100.0
3
/3
IMA1_HUMAN Importin subunit alpha-1
3wpt[1] D PEG
DI(HYDROXYETHYL)ETHER[7 atoms]
A 100.0
/100.0
3
/3
IMA1_HUMAN Importin subunit alpha-1
3wpt[1] G PEG
DI(HYDROXYETHYL)ETHER[7 atoms]
A 100.0
/100.0
1
/1
IMA1_HUMAN Importin subunit alpha-1
3wpt[1] R PEG
DI(HYDROXYETHYL)ETHER[7 atoms]
B 100.0
/100.0
3
/3
IMA1_HUMAN Importin subunit alpha-1
3wpt[1] H PEG
DI(HYDROXYETHYL)ETHER[7 atoms]
A 100.0
/100.0
6
/6
IMA1_HUMAN Importin subunit alpha-1
3wpt[1] F PEG
DI(HYDROXYETHYL)ETHER[7 atoms]
A 100.0
/100.0
1
/1
IMA1_HUMAN Importin subunit alpha-1
3wpt[1] S PEG
DI(HYDROXYETHYL)ETHER[7 atoms]
B 100.0
/100.0
3
/3
IMA1_HUMAN Importin subunit alpha-1
3wpt[1] E PEG
DI(HYDROXYETHYL)ETHER[7 atoms]
A 100.0
/100.0
5
/5
IMA1_HUMAN Importin subunit alpha-1
3wpt[1] L PEG
DI(HYDROXYETHYL)ETHER[7 atoms]
A 100.0
/100.0
2
/2
IMA1_HUMAN Importin subunit alpha-1
3wpt[1] J PEG
DI(HYDROXYETHYL)ETHER[7 atoms]
A 100.0
/100.0
3
/3
IMA1_HUMAN Importin subunit alpha-1
3wpt[1] I PEG
DI(HYDROXYETHYL)ETHER[7 atoms]
A 100.0
/100.0
1
/1
IMA1_HUMAN Importin subunit alpha-1
4wv6[1] E EDO
1,2-ETHANEDIOL[4 atoms]
A 100.0
/100.0
2
/2
IMA1_HUMAN Importin subunit alpha-1
4wv6[1] J EDO
1,2-ETHANEDIOL[4 atoms]
A 100.0
/100.0
4
/4
IMA1_HUMAN Importin subunit alpha-1
4wv6[1] L EDO
1,2-ETHANEDIOL[4 atoms]
A 100.0
/100.0
3
/3
IMA1_HUMAN Importin subunit alpha-1
4wv6[1] K EDO
1,2-ETHANEDIOL[4 atoms]
A 100.0
/100.0
3
/3
IMA1_HUMAN Importin subunit alpha-1
4wv6[1] H EDO
1,2-ETHANEDIOL[4 atoms]
A 100.0
/100.0
5
/5
IMA1_HUMAN Importin subunit alpha-1
4wv6[1] M EDO
1,2-ETHANEDIOL[4 atoms]
A 100.0
/100.0
3
/3
IMA1_HUMAN Importin subunit alpha-1
4wv6[1] F EDO
1,2-ETHANEDIOL[4 atoms]
A 100.0
/100.0
4
/4
IMA1_HUMAN Importin subunit alpha-1
4wv6[1] I EDO
1,2-ETHANEDIOL[4 atoms]
A 100.0
/100.0
3
/3
IMA1_HUMAN Importin subunit alpha-1
4wv6[1] N EDO
1,2-ETHANEDIOL[4 atoms]
A 100.0
/100.0
2
/2
IMA1_HUMAN Importin subunit alpha-1
4wv6[3] G EDO
1,2-ETHANEDIOL[4 atoms]
A 100.0
/100.0
4
/4
IMA1_HUMAN Importin subunit alpha-1
3.a3:asym_id for the contact molecule. 4.a4:asym_id for the template homologue. 5.identity[%]5:sequence identity between the query and the template homologue only for the contact residues. Number after the slash / is sequence identity for all the aligned region. 6.Ncon6:number of aligned contact residues for the query. Number after the slash / is number of contact residues in the template homologue.