ID   NS6_WCPV                Reviewed;          61 AA.
AC   P0DTC6;
DT   22-APR-2020, integrated into UniProtKB/Swiss-Prot.
DT   22-APR-2020, sequence version 1.
DT   22-APR-2020, entry version 1.
DE   RecName: Full=Non-structural protein 6;
DE            Short=ns6;
DE   AltName: Full=Accessory protein 6;
DE   AltName: Full=Protein X3;
GN   ORFNames=6;
OS   Wuhan seafood market pneumonia virus.
OC   Viruses; Riboviria; Nidovirales; Cornidovirineae; Coronaviridae;
OC   Orthocoronavirinae; Betacoronavirus; unclassified Betacoronavirus.
OX   NCBI_TaxID=2697049;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RA   Wu F., Zhao S., Yu B., Chen Y.-M., Wang W., Hu Y., Song Z.-G., Tao Z.-W.,
RA   Tian J.-H., Pei Y.-Y., Yuan M.L., Zhang Y.-L., Dai F.-H., Liu Y.,
RA   Wang Q.-M., Zheng J.-J., Xu L., Holmes E.C., Zhang Y.-Z.;
RT   "A novel coronavirus associated with a respiratory disease in Wuhan of
RT   Hubei province, China.";
RL   Submitted (JAN-2020) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Could be a determinant of virus virulence, since, when
CC       expressed in an otherwise attenuated JHM strain of murine coronavirus,
CC       it can dramatically increase the lethality of the latter. Seems to
CC       stimulate cellular DNA synthesis in vitro.
CC       {ECO:0000250|UniProtKB:P59634}.
CC   -!- SUBCELLULAR LOCATION: Host endoplasmic reticulum membrane
CC       {ECO:0000250|UniProtKB:P59634}. Host Golgi apparatus membrane
CC       {ECO:0000250|UniProtKB:P59634}.
CC   -!- MISCELLANEOUS: nCoV is the prototype of the virus isolated during the
CC       severe coronavirus outbreak in originated in Wuhan in 2020.
CC       {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the coronaviruses accessory protein 6 family.
CC       {ECO:0000305}.
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DR   EMBL; MN908947; QHD43420.1; -; Genomic_RNA.
DR   InterPro; IPR022736; SARS_NS6.
DR   Pfam; PF12133; Sars6; 1.
PE   3: Inferred from homology;
KW   Host endoplasmic reticulum; Host Golgi apparatus; Host membrane; Membrane;
KW   Virulence.
FT   CHAIN           1..61
FT                   /note="Non-structural protein 6"
FT                   /id="PRO_0000449653"
SQ   SEQUENCE   61 AA;  7273 MW;  B21BD303F59A1D0A CRC64;
     MFHLVDFQVT IAEILLIIMR TFKVSIWNLD YIINLIIKNL SKSLTENKYS QLDEEQPMEI
     D
//