ID   NS7A_WCPV               Reviewed;         121 AA.
AC   P0DTC7;
DT   22-APR-2020, integrated into UniProtKB/Swiss-Prot.
DT   22-APR-2020, sequence version 1.
DT   22-APR-2020, entry version 1.
DE   RecName: Full=Protein 7a;
DE   AltName: Full=Accessory protein 7a;
DE   AltName: Full=Protein U122;
DE   AltName: Full=Protein X4;
DE   Flags: Precursor;
GN   ORFNames=7a;
OS   Wuhan seafood market pneumonia virus.
OC   Viruses; Riboviria; Nidovirales; Cornidovirineae; Coronaviridae;
OC   Orthocoronavirinae; Betacoronavirus; unclassified Betacoronavirus.
OX   NCBI_TaxID=2697049;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RA   Wu F., Zhao S., Yu B., Chen Y.-M., Wang W., Hu Y., Song Z.-G., Tao Z.-W.,
RA   Tian J.-H., Pei Y.-Y., Yuan M.L., Zhang Y.-L., Dai F.-H., Liu Y.,
RA   Wang Q.-M., Zheng J.-J., Xu L., Holmes E.C., Zhang Y.-Z.;
RT   "A novel coronavirus associated with a respiratory disease in Wuhan of
RT   Hubei province, China.";
RL   Submitted (JAN-2020) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Non-structural protein which is dispensable for virus
CC       replication in cell culture. {ECO:0000250|UniProtKB:P59635}.
CC   -!- SUBUNIT: Interacts with the spike glycoprotein, M protein, E protein
CC       and the accessory protein 3a. Interacts with human SGT.
CC       {ECO:0000250|UniProtKB:P59635}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000250|UniProtKB:P59635}. Host
CC       endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P59635}; Single-
CC       pass membrane protein {ECO:0000250|UniProtKB:P59635}. Host endoplasmic
CC       reticulum-Golgi intermediate compartment membrane
CC       {ECO:0000250|UniProtKB:P59635}; Single-pass type I membrane protein
CC       {ECO:0000250|UniProtKB:P59635}. Host Golgi apparatus membrane
CC       {ECO:0000250|UniProtKB:P59635}; Single-pass membrane protein
CC       {ECO:0000250|UniProtKB:P59635}.
CC   -!- DOMAIN: The di-lysine motif confers endoplasmic reticulum localization
CC       for type I membrane proteins. {ECO:0000250|UniProtKB:P59635}.
CC   -!- MISCELLANEOUS: nCoV is the prototype of the virus isolated during the
CC       severe coronavirus outbreak in originated in Wuhan in 2020.
CC       {ECO:0000305}.
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DR   EMBL; MN908947; QHD43421.1; -; Genomic_RNA.
DR   Gene3D; 2.60.40.1550; -; 1.
DR   InterPro; IPR014888; SARS_X4.
DR   InterPro; IPR036495; SARS_X4_sf.
DR   Pfam; PF08779; SARS_X4; 1.
DR   SUPFAM; SSF117066; SSF117066; 1.
PE   3: Inferred from homology;
KW   G0/G1 host cell cycle checkpoint dysregulation by virus;
KW   Host endoplasmic reticulum; Host Golgi apparatus; Host membrane;
KW   Host-virus interaction; Membrane; Modulation of host cell cycle by virus;
KW   Signal; Transmembrane; Transmembrane helix; Virion.
FT   SIGNAL          1..15
FT                   /evidence="ECO:0000255"
FT   CHAIN           16..121
FT                   /note="Protein 7a"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000449654"
FT   TRANSMEM        96..116
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   MOTIF           117..121
FT                   /note="Di-lysine motif"
FT                   /evidence="ECO:0000250|UniProtKB:P59635"
SQ   SEQUENCE   121 AA;  13744 MW;  891E7EAB9E8A5BA9 CRC64;
     MKIILFLALI TLATCELYHY QECVRGTTVL LKEPCSSGTY EGNSPFHPLA DNKFALTCFS
     TQFAFACPDG VKHVYQLRAR SVSPKLFIRQ EEVQELYSPI FLIVAAIVFI TLCFTLKRKT
     E
//