ID   NS8_SARS2               Reviewed;         121 AA.
AC   P0DTC8;
DT   22-APR-2020, integrated into UniProtKB/Swiss-Prot.
DT   22-APR-2020, sequence version 1.
DT   17-JUN-2020, entry version 2.
DE   RecName: Full=Non-structural protein 8;
DE            Short=ns8;
DE   Flags: Precursor;
OS   Severe acute respiratory syndrome coronavirus 2 (2019-nCoV) (SARS-CoV-2).
OC   Viruses; Riboviria; Nidovirales; Cornidovirineae; Coronaviridae;
OC   Orthocoronavirinae; Betacoronavirus; Sarbecovirus.
OX   NCBI_TaxID=2697049;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=32015508; DOI=10.1038/s41586-020-2008-3;
RA   Wu F., Zhao S., Yu B., Chen Y.-M., Wang W., Song Z.-G., Hu Y., Tao Z.-W.,
RA   Tian J.-H., Pei Y.-Y., Yuan M.-L., Zhang Y.-L., Dai F.-H., Liu Y.,
RA   Wang Q.-M., Zheng J.-J., Xu L., Holmes E.C., Zhang Y.-Z.;
RT   "A new coronavirus associated with human respiratory disease in China.";
RL   Nature 579:265-269(2020).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RC   STRAIN=isolate 2019-nCoV_HKU-SZ-002a_2020;
RX   PubMed=31986261; DOI=10.1016/s0140-6736(20)30154-9;
RA   Chan J.F., Yuan S., Kok K.H., To K.K., Chu H., Yang J., Xing F., Liu J.,
RA   Yip C.C., Poon R.W., Tsoi H.W., Lo S.K., Chan K.H., Poon V.K., Chan W.M.,
RA   Ip J.D., Cai J.P., Cheng V.C., Chen H., Hui C.K., Yuen K.Y.;
RT   "A familial cluster of pneumonia associated with the 2019 novel coronavirus
RT   indicating person-to-person transmission: a study of a family cluster.";
RL   Lancet 395:514-523(2020).
CC   -!- FUNCTION: May play a role in host-virus interaction. {ECO:0000305}.
CC   -!- MISCELLANEOUS: Simnilar to some Bat coronavirus ns8 genes, but is
CC       entirely different from SARS ns8a or Ns8b. {ECO:0000305}.
DR   EMBL; MN908947; QHD43422.1; -; Genomic_RNA.
DR   EMBL; MN938384; -; NOT_ANNOTATED_CDS; Genomic_RNA.
DR   IntAct; P0DTC8; 47.
DR   Proteomes; UP000464024; Genome.
DR   InterPro; IPR022722; Corona_NS8.
DR   Pfam; PF12093; bCoV_NS8; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Signal.
FT   SIGNAL          1..15
FT                   /evidence="ECO:0000255"
FT   CHAIN           16..121
FT                   /note="Non-structural protein 8"
FT                   /id="PRO_0000449655"
FT   VARIANT         84
FT                   /note="L -> S (in isolate 2019-nCoV_HKU-SZ-002a_2020)"
SQ   SEQUENCE   121 AA;  13831 MW;  912AD9E147A64907 CRC64;
     MKFLVFLGII TTVAAFHQEC SLQSCTQHQP YVVDDPCPIH FYSKWYIRVG ARKSAPLIEL
     CVDEAGSKSP IQYIDIGNYT VSCLPFTINC QEPKLGSLVV RCSFYEDFLE YHDVRVVLDF
     I
//