ID   ORF9B_SARS2             Reviewed;          97 AA.
AC   P0DTD2;
DT   22-APR-2020, integrated into UniProtKB/Swiss-Prot.
DT   22-APR-2020, sequence version 1.
DT   17-JUN-2020, entry version 2.
DE   RecName: Full=Protein 9b;
DE   AltName: Full=Accessory protein 9b;
DE   AltName: Full=ORF-9b;
OS   Severe acute respiratory syndrome coronavirus 2 (2019-nCoV) (SARS-CoV-2).
OC   Viruses; Riboviria; Nidovirales; Cornidovirineae; Coronaviridae;
OC   Orthocoronavirinae; Betacoronavirus; Sarbecovirus.
OX   NCBI_TaxID=2697049;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=32015508; DOI=10.1038/s41586-020-2008-3;
RA   Wu F., Zhao S., Yu B., Chen Y.-M., Wang W., Song Z.-G., Hu Y., Tao Z.-W.,
RA   Tian J.-H., Pei Y.-Y., Yuan M.-L., Zhang Y.-L., Dai F.-H., Liu Y.,
RA   Wang Q.-M., Zheng J.-J., Xu L., Holmes E.C., Zhang Y.-Z.;
RT   "A new coronavirus associated with human respiratory disease in China.";
RL   Nature 579:265-269(2020).
CC   -!- FUNCTION: May play a role in host-virus interaction. {ECO:0000305}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250|UniProtKB:P59636}.
CC   -!- SUBCELLULAR LOCATION: Host cytoplasmic vesicle membrane
CC       {ECO:0000250|UniProtKB:P59636}; Peripheral membrane protein
CC       {ECO:0000250|UniProtKB:P59636}. Host cytoplasm
CC       {ECO:0000250|UniProtKB:P59636}. Note=Binds non-covalently to
CC       intracellular lipid bilayers. {ECO:0000250|UniProtKB:P59636}.
CC   -!- MISCELLANEOUS: The gene encoding this protein is included within the N
CC       gene (alternative ORF). {ECO:0000250|UniProtKB:P59636}.
CC   -!- SIMILARITY: Belongs to the coronavirus group 2 protein 9b family.
CC       {ECO:0000305}.
DR   EMBL; MN908947; -; NOT_ANNOTATED_CDS; Genomic_RNA.
DR   IntAct; P0DTD2; 11.
DR   Proteomes; UP000464024; Genome.
DR   GO; GO:0044162; C:host cell cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR018542; SARS_lipid-bd.
DR   InterPro; IPR037223; SARS_ORF-9b.
DR   Pfam; PF09399; bCoV_lipid_BD; 1.
DR   SUPFAM; SSF141666; SSF141666; 1.
DR   PROSITE; PS51920; SARS_9B; 1.
PE   3: Inferred from homology;
KW   Host cytoplasm; Host cytoplasmic vesicle; Host membrane; Membrane;
KW   Reference proteome.
FT   CHAIN           1..97
FT                   /note="Protein 9b"
FT                   /evidence="ECO:0000250|UniProtKB:P59636"
FT                   /id="PRO_0000449657"
FT   DOMAIN          8..97
FT                   /note="9b"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01268"
SQ   SEQUENCE   97 AA;  10797 MW;  62CFB65C1804545E CRC64;
     MDPKISEMHP ALRLVDPQIQ LAVTRMENAV GRDQNNVGPK VYPIILRLGS PLSLNMARKT
     LNSLEDKAFQ LTPIAVQMTK LATTEELPDE FVVVTVK
//